ABSTRACT
A prospective study was performed to evaluate the efficacy and safety of concurrent chemotherapy with single agent low dose Carboplatin and radiotherapy on survival, functional and quality of life outcomes in locally advanced head and neck cancer patients. Material and Methods : Sixty inoperable, previously untreated locally advanced head and neck cancer patients were planned to be treated with radical radiotherapy 66 Gy with concurrent single agent chemotherapy with low dose Carboplatin 150 mg IV weekly up to 6.3 weeks (Group A) and conventional radical radiotherapy alone (Group B). Results : After completion of therapy in Group A complete response was observed in 19/30 (63%) patient and in control group B in 10/30 (33%).Grade II mucosal toxicities were observed in 40% of cases and 33 % of cases in study and control group respectively. Conclusion : Concomitant single agent chemo radiotherapy with low dose Carboplatin could be a better choice in advanced stage of Head and Neck carcinoma in terms of survival, acceptable toxicities together with enhanced response and quality of life.
Subject(s)
Carboplatin/administration & dosage , Carboplatin/therapeutic use , Combined Modality Therapy , Female , Head and Neck Neoplasms/drug therapy , Head and Neck Neoplasms/radiotherapy , Humans , Male , Middle Aged , Radiotherapy , Radiotherapy DosageABSTRACT
Introdução: A tendência dos pacientes com carcinoma da cabeça e pescoço (CCP) é cursar com desnutrição e caquexia. Objetivo: Avaliar o estado nutricional (EN) do paciente com CCP antes e durante a quimioterapia com o uso da cisplatina no ambulatório de quimioterapia de um hospital público de São Paulo. Método: Por meio da elaboração de um questionário de efeitos colaterais (DEC) as reações foram avaliadas juntamente com a avaliação antropométrica. Resultados: Apesar da cisplatina, 100% dos pacientes não apresentaram emese, observou-se que 83% faziam radioterapia e quimioterapia associadas, sendo que 50% destes haviam feito cirurgia. Conclusão: Os danos provocados pela cisplatina são menores do que o diagnóstico tardio, que é o verdadeiro responsável pelo prognóstico reservado do paciente de CCP, pois, além de limitar a qualidade de vida, eleva muitos os custos do tratamento.
Introduction: The tendency of patients with carcinoma of the head and neck (CCP) is present with malnutrition and cachexia. Objective: To evaluate the nutritional status (EN) of patients with PBC before and during chemotherapy using cisplatin chemotherapy in the outpatient clinic of a public hospital in São Paulo. Method: Through the development of a questionnaire on side effects (DEC) reactions were evaluated with anthropometric measurements. Results: Although cisplatin, 100% of patients had no emesis was observed that 83% were associated with radiotherapy and chemotherapy, and 50% of these had surgery done. Conclusion: The damage caused by cisplatin are smaller than late diagnosis, which is the true responsible for the prognosis of PBC patients, because in addition to limiting the quality of life raises many of the costs of treatment.
Introducción: La tendencia de los pacientes con carcinoma de cabeza y cuello (CCP) se presenta con la desnutrición y caquexia. Objetivo: Evaluar el estado nutricional (EN) de los pacientes con PBC antes y durante la quimioterapia con cisplatino en la clínica ambulatoria de un hospital público de São Paulo. Método: Mediante el desarrollo de un cuestionario sobre los efectos secundarios (DEC), las reacciones fueron evaluados con las medidas antropométricas. Resultados: Aunque el cisplatino, el 100% de los pacientes no emesis se observó que 83% estaban asociados con la radioterapia y la quimioterapia, y hecho el 50% de estos tenían la cirugía. Conclusión: Los daños causados por el cisplatino es menor que el diagnóstico tardío, que es el responsable de verdad para el pronóstico de los pacientes con CBP, ya que además de limitar la calidad de vida plantea muchos de los costos del tratamiento.